DRUG-INDUCED PAROTITIS

Drug-induced parotitis is a relatively uncommon adverse drug reaction. Most of the data on drug-induced parotitis consist of isolated case r eports with few attempts at rechallenge to confirm the aetiology. Phen ylbutazone and oxyphenbutazone have a significant number of reports su ggesting that these drugs may be implicated in causing parotitis. Anti psychotics, particularly thioridazine, have been associated with parot itis. Most of these reports relate the anticholinergic oral drying as a predisposing factor in the development of a parotid gland infection. There is inadequate literature on the histamine (H-2) receptor blocke rs, interferon-alpha, doxycycline, trimipramine, nifedipine, methyldop a, nitrofurantoin, nicardipine, isoproterenol or ritodrine to link the m as aetiological agents in the development of parotitis.