THE DEVELOPMENT OF ORAL LIQUID DOSAGE FORMS OF METRONIDAZOLE

The stability of eight samples of metronidazole in aqueous vehicles wa s studied using a modified HPLC assay method. The samples were prepare d using either metronidazole powder (5 mg/ml), metronidazole hydrochlo ride injection powder (10 mg/ml), or metronidazole powdered tablets (1 0 mg/ml). The samples prepared using metronidazole hydrochloride powde r were stable and clear for at least 133 days at 25-degrees-C. Their p H values were between 1.8 and 2.0. The samples prepared from metronida zole powder had pH values close to neutral and were stable for at leas t 45 days at room temperature (25-degrees-C). However, to keep the dru g in solution, the concentration of metronidazole powder was reduced t o 5 mg/ml. The powdered tablets did not yield good uniform suspensions .