QT PROLONGATION BY ISOPROTERENOL IN ANOREXIA-NERVOSA

A 17-year-old male with anorexia nervosa developed atypical prolongati on of his corrected QT interval (QTc) when placed on isoproterenol for profound sinus bradycardia. His QTc normalized after the infusion was discontinued. Autonomic imbalance may explain the observed QTc length ening. Because bradycardia associated with weight loss in anorexia is usually a physiologic adaptation and rarely symptomatic, aggressive ch ronotropic therapy may be not only unwarranted, but potentially delete rious.