AN ENANTIODIVERGENT SYNTHESIS OF THREO BETA-AMINO ALCOHOLS - PREPARATION OF KEY INTERMEDIATES FOR BESTATIN AND THE RELATED PEPTIDES

Authors
KAWABATA T KIRYU Y SUGIURA Y FUJI K
Citation
T. Kawabata et al., AN ENANTIODIVERGENT SYNTHESIS OF THREO BETA-AMINO ALCOHOLS - PREPARATION OF KEY INTERMEDIATES FOR BESTATIN AND THE RELATED PEPTIDES, Tetrahedron letters, 34(32), 1993, pp. 5127-5130
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
32
Year of publication
1993
Pages
5127 - 5130
Database
ISI
SICI code
0040-4039(1993)34:32<5127:AESOTB>2.0.ZU;2-E
Abstract
An enantiodivergent method for preparation of threo beta-amino alcohol s and threo 1,2-diamines has been developed starting with a chiral azi ridine 1. Unusual amino acid derivatives 3 and 5, which are key synthe tic intermediates for bestatin and the related peptides, have been pre pared.