COMPARATIVE DISSOLUTION CHARACTERISTICS OF BROPIRIMINE-BETA-CYCLODEXTRIN INCLUSION COMPLEX AND ITS SOLID DISPERSION WITH PEG-6000

An inclusion complex of bropirimine (ABPP) with beta-cyclodextrin (bet aCD) and its solid dispersion with polyethylene glycol 6000 (PEG 6000) were prepared by the coprecipitation method. Comparative dissolution studies revealed that the solid complex exhibited a markedly faster di ssolution rate compared to the PEG 6000 solid dispersions and physical mixtures in water and phosphate buffer (pH 7.4). However, the dissolu tion of all the test preparations was enhanced to almost the same exte nt in 0.1 N HCI. H-1-NMR was employed to confirm the inclusion of the drug within the beta-CD cavity. The high solubility and instant releas e of the drug were maintained upon ageing of the solid complex for 1 y ear, while the release of the solid dispersions decreased. TLC investi gations proved that this decrease in the release rate was not due to d rug degradation.