CORRELATION OF COLLOIDAL MICROSTRUCTURE, DRUG-RELEASE AND PERMEATION THROUGH EXCISED HUMAN SKIN

For lamellar vehicles composed of lecithin, isopropyl myristate (IPM) and water, a phase transition into reversed hexagonal systems was obse rved on the addition of fenoprofen acid. Furthermore, the solubilizati on capacity for IPM was increased. An excess of oil resulted in revers ed micellar solutions. The colloidal microstructure was characterized by polarized light microscopy, small-angle X-ray diffraction and trans mission electron microscopy. Drug release from the systems increased w ith increasing content of IPM. The same trend was observed for drug pe rmeation through excised human skin.