PERCOLATION THEORY - APPLICATION TO THE STUDY OF THE RELEASE BEHAVIORFROM INERT MATRIX SYSTEMS

In the present paper, release profiles obtained from matrix tablets pr epared with Eudragit(R) RS-KCl and a usual eccentric machine were stud ied. The results were in agreement with previously reported release st udies for compacts prepared using a hydraulic press. The most outstand ing aspect is the study of the influence of the particle size of drug and excipient on the release behaviour of the matrices, and its evalua tion on the basis of percolation theory. The influence of soluble drug loading has also been studied. This new theory has been shown to be a useful tool to explain the release profiles from inert matrix compres sed tablets.