L. Hellen et al., PROCESS VARIABLES OF INSTANT GRANULATOR AND SPHERONISER .1. PHYSICAL-PROPERTIES OF GRANULES, EXTRUDATE AND PELLETS, International journal of pharmaceutics, 96(1-3), 1993, pp. 197-204
The influence of process variables of a continuously working instant N
ica granulator, and those of a spheroniser on the stability of moistur
e content during the process, the surface morphology, friability, pack
ing and flow properties of pellets was evaluated. A complete six-facto
r, two-level study design was used. The moisture content of granules a
nd extrudate corresponded well to the amount of water used as a granul
ation liquid. Hence, until the spheronisation stage, the stability of
moisture content was maintained. During spheronisation, the moisture c
ontent decreased due to the effect of residence time and friction plat
e speed. The surface morphology of pellets was dependent on the amount
of water used; with a higher water amount the surface was smoother. T
he process variables of the spheroniser explained most significantly t
he changes in packing properties of pellets: the bulk and tapped densi
ty increased with increasing load, time and speed in the spheroniser.