STUDY OF PARAMETERS IMPORTANT IN THE SPHERONIZATION PROCESS

Authors
BAERT L VERMEERSCH H REMON JP SMEYERSVERBEKE J MASSART DL
Citation
L. Baert et al., STUDY OF PARAMETERS IMPORTANT IN THE SPHERONIZATION PROCESS, International journal of pharmaceutics, 96(1-3), 1993, pp. 225-229
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
96
Issue
1-3
Year of publication
1993
Pages
225 - 229
Database
ISI
SICI code
0378-5173(1993)96:1-3<225:SOPIIT>2.0.ZU;2-F
Abstract
An experimental design was used to determine the influence of paramete rs that are important in the extrusion-spheronisation process. The par ameters tested were water content of binary mixtures of Avicel PH 101( R)/water, spheroniser speed and spheronisation time. They appeared to have a significant influence on the quality of the spheres. By using a Pareto analysis, optimal parameter settings for water content, sphero niser speed and spheronising time were obtained.