BISTRAMIDE-A-INDUCED IRREVERSIBLE ARREST OF CELL-PROLIFERATION IN A NON-SMALL-CELL BRONCHOPULMONARY CARCINOMA IS SIMILAR TO INDUCTION OF TERMINAL MATURATION

Authors
RIOU D ROUSSAKIS C ROBILLARD N BIARD JF VERBIST JF
Citation
D. Riou et al., BISTRAMIDE-A-INDUCED IRREVERSIBLE ARREST OF CELL-PROLIFERATION IN A NON-SMALL-CELL BRONCHOPULMONARY CARCINOMA IS SIMILAR TO INDUCTION OF TERMINAL MATURATION, Biology of the cell, 77(3), 1993, pp. 261-264
Citations number
16
Categorie Soggetti
Cytology & Histology
Journal title
Biology of the cell → ACNP
ISSN journal
02484900
Volume
77
Issue
3
Year of publication
1993
Pages
261 - 264
Database
ISI
SICI code
0248-4900(1993)77:3<261:BIAOCI>2.0.ZU;2-W
Abstract
Bistramide A, a new toxin isolated from a New Caledonian Urochordata, shows an antiproliferative effect on a non-small-cell lung carcinoma l ine in vitro and G1-blockade. In this work, the growth arrest induced by bistramide A was shown to be irreversible as assessed by growth kin etics of pretreated cells. Furthermore, the drug caused an underexpres sion of the nuclear antigen Ki67. These events are similar to a G1-dif ferentiation cell cycle step blockage and a terminal maturation induct ion.