MINIATURIZED SINGLE-PHOTON FLUOROMETRY

We report the miniaturization of single-photon timing fluorescence lif etime spectroscopy using picosecond diode laser excitation and liquid light guide collection of different time-correlated signals in a multi plexed arrangement. Liquid light guide coupling permits multiple chann els of fluorescence decay information with respect to wavelength, pola rization, sensor, etc, to be collected simultaneously and eliminates a common source of error in convolution analysis. The instrumental perf ormance is demonstrated in a study of perylene fluorescence quenched b y cobalt ions in micelles.