THE HYPOLIPIDEMIC EFFECTS OF 1-ACETYL-4-PHENYL-1,2,4-TRIAZOLIDINE-3,5-DIONE IN RODENTS

1-Acetyl-4-phenyl-1,2,4-triazolidine,5-dione (APTD), a potent hypolipi demic agent, lowered both serum cholesterol and triglyceride levels in normo- and hyperlipidemic rats at 10 or 20 mg/kg/day. The agent effec tively lowered VLDL-cholesterol (VLDL-C) and LDL-C content and raised HDL-C content in normal and hyperlipidemic rats treated from 4 to 8 we eks. Similar effects on the incorporation of cholesterol into the lipo protein fractions were observed after drug treatment. Tissue lipids, e .g. cholesterol, were lowered, whereas fecal cholesterol levels were i ncreased. APTD's primary targets were acyl CoA cholesterol acyl transf erase (ACAT) for cholesterol ester synthesis and sn-glycerol-3-phospha te acyl transferase (GPAT) and phosphatidylate phosphohydrolase (PPH) for triglyceride synthesis.