FATAL ACUTE LIVER-FAILURE - A RARE COMPLI CATION OF EXERTIONAL HEAT-STROKE

Liver injury is a well-known complication of exertional heat stroke. H owever severe acute irreversible liver dysfunction is rarely associate d. Persistent centrolobular hepatocellular necrosis without any regene ration remains very uncommon. We report a case of fatal acute liver fa ilure occurring after exertional heat stroke. Despite the conventional symptomatic treatment, especially active cooling, the patient experie nced multiple organ failure with brain death 6 days after his admissio n. In this case, a chronic treatment with neuroleptic and anticholiner gic agents may be considered as a predisposing factor.