A double-blind placebo-controlled study was carried out in 14 subjects
to investigate the effect of naftidrofuryl in the treatment of rest c
ramp. Naftidrofuryl caused a significant reduction in cramp frequency
(median naftidrofuryl = 5; median placebo = 17; P < 0.004) and ar sign
ificant 34% increase in cramp free days (median naftidrofuryl = 22; me
dian placebo = 14; P<0.004). Naftidrofuryl is an effective alternative
to quinine in the treatment of this painful condition.