Amhp. Vandenbesselaar et J. Meeuwissebraun, ENZYMATIC ELIMINATION OF HEPARIN FROM PLASMA FOR ACTIVATED PARTIAL THROMBOPLASTIN TIME AND PROTHROMBIN TIME TESTING, Blood coagulation & fibrinolysis, 4(4), 1993, pp. 635-638
The prolongation of the APTT and PT by heparin can be neutralized by t
reating the plasma with heparinase or with certain anion-exchangers. T
he purpose of the present study was to assess the effectiveness of a n
ew commercial heparinase reagent. Heparinase (Hepzyme(TM)) for the rem
oval of heparin from plasma was compared with ECTEOLA-cellulose treatm
ent. In ex vivo heparin samples, shorter APTT values were obtained wit
h heparinase than with ECTEOLA-cellulose, suggesting that the former t
reatment is more effective for the removal of heparin from plasma. Hep
arinase (Hepzyme(TM)) treatment may be used to improve INR assessment
in patients treated with heparin and oral anticoagulants concomitantly
.