We used an alternative technique for regional citrate anticoagulation
(citrate 0.48 Mol; bicarbonate containing dialysate with Ca 1.75 Mmol)
in three patients at chronic risk of bleeding and for a mean follow-u
p period of ten months. No bleeding recurrence was observed nor any co
mplication related to citrate. Hemoglobin and hematocrit rose without
transfusions. Serum bicarbonate increased during the first four months
of treatment. No significant change was observed in serum calcium nor
serum sodium concentration.