RECENT ADVANCES IN BOVINE VACCINE TECHNOLOGY

Authors
Citation
Rj. Yancey, RECENT ADVANCES IN BOVINE VACCINE TECHNOLOGY, Journal of dairy science, 76(8), 1993, pp. 2418-2436
Citations number
172
Categorie Soggetti
Agriculture Dairy & AnumalScience","Food Science & Tenology
Journal title
ISSN journal
00220302
Volume
76
Issue
8
Year of publication
1993
Pages
2418 - 2436
Database
ISI
SICI code
0022-0302(1993)76:8<2418:RAIBVT>2.0.ZU;2-Z
Abstract
A description of new commercial and experimental vaccines for viral an d bacterial diseases of cattle can be broadly divided into those used for both beef and dairy cows and those used predominantly in dairy cat tle. For both types of cattle, newer and experimental vaccines are dir ected against several of the important viral (e.g., bovine herpesvirus 1, bovine viral diarrhea virus, bovine respiratory syncytial virus, p arainfluenza type 3, and foot-and-mouth disease virus) and bacterial p athogens (e.g., Pasteurella spp., Haemophilus somnus). The viral vacci nes include gene-deleted, modified live, subunit, and peptide antigens . Newer bacterial vaccines, particularly those for Pasteurella spp., a re composed of either modified-live vaccines or bacterins supplemented with toxoid or surface antigens. Haemophilus somnus vaccine research has concentrated mainly on defining unique surface antigens. Novel dai ry cow vaccines would include the lipopolysaccharide-core (J5) antigen approach, which has been used for successful immunization against col iform mastitis. Core antigen vaccines also have reduced calf mortality from Gram-negative pathogens. Staphylococcal mastitis vaccines that c ontain capsular antigens, toxoids, or the staphylococcal fibronectin r eceptor are of active research interest. Vaccines against mastitis ind uced by Streptococcus agalactiae and Streptococcus uberis also are are as of intensive research. Delivery of multiple subunit antigens with o ptimal immune response induction has led to the investigation of atten uated heterologous viral and bacterial expression vectors such as bovi ne herpesvirus 1, vaccinia, and Salmonella spp. This discussion also d emonstrates that molecular biology is being used to advance bovine vac cine technology.