M. Radkowski et al., AFFINITY OF ANTI-GP41 ANTIBODY IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, European journal of clinical investigation, 23(8), 1993, pp. 455-458
Anti-gp41 antibody affinity was investigated prospectively in 25 patie
nts with asymptomatic and symptomatic HIV-1 infection for a period of
9-42 months. Major differences in the processs of immune response matu
ration towards gp41 were observed among individual subjects, however,
antibody affinity increased with time in all examined persons includin
g patients with AIDS. Anti-gp41 affinity values were found to reflect
both the duration and the clinical stage of HIV infection