THE ROLE OF THE SODIUM-PUMP AND SODIUM-CALCIUM EXCHANGE IN RECOVERY FROM CALCIUM OVERLOAD IN GUINEA-PIG VENTRICULAR MYOCYTES

Authors
MINEZAKI KK CHAPMAN RA
Citation
Kk. Minezaki et Ra. Chapman, THE ROLE OF THE SODIUM-PUMP AND SODIUM-CALCIUM EXCHANGE IN RECOVERY FROM CALCIUM OVERLOAD IN GUINEA-PIG VENTRICULAR MYOCYTES, Experimental physiology, 78(4), 1993, pp. 545-548
Citations number
8
Categorie Soggetti
Physiology
Journal title
Experimental physiology → ACNP
ISSN journal
09580670
Volume
78
Issue
4
Year of publication
1993
Pages
545 - 548
Database
ISI
SICI code
0958-0670(1993)78:4<545:TROTSA>2.0.ZU;2-9
Abstract
A marked increase in [Ca2+]i is provoked in isolated guinea-pig ventri cular myocytes by return to normal Tyrode solution after a period of e xposure to fluid free of divalent cations. When the sarcolemma of the myocyte remains intact, [Ca2+]i falls back towards initial levels over the next 5 to 10 min in spite of the strong irreversible contracture. This recovery fails to occur if either the Na+ pump or Na+-Ca2+ excha nge is inhibited once [Ca2+]i has risen.