REPRODUCTIVE HORMONES MODULATE ANGIOTENSIN-II AT1 RECEPTORS IN THE DORSOMEDIAL ARCUATE NUCLEUS OF THE FEMALE RAT

Authors
SELTZER A TSUTSUMI K SHIGEMATSU K SAAVEDRA JM
Citation
A. Seltzer et al., REPRODUCTIVE HORMONES MODULATE ANGIOTENSIN-II AT1 RECEPTORS IN THE DORSOMEDIAL ARCUATE NUCLEUS OF THE FEMALE RAT, Endocrinology, 133(2), 1993, pp. 939-941
Citations number
16
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Endocrinology → ACNP
ISSN journal
00137227
Volume
133
Issue
2
Year of publication
1993
Pages
939 - 941
Database
ISI
SICI code
0013-7227(1993)133:2<939:RHMAAR>2.0.ZU;2-G
Abstract
Angiotensin II AT1 receptors are highly localized in the dorsomedial a rcuate nucleus. AT1 receptor number is very low during proestrus and i n ovariectomized and male rats, and is high only during the estrus pha se of the estrous cycle and after ovariectomized rats receive a sequen tial estrogen-progesterone treatment. Our results suggest that the mec hanism of the estrogen-progesterone inhibition of the prolactin surge may involve the selective stimulation of dorsomedial arcuate AT1 recep tors.