TRAFFICKING OF LYSOSOMAL MEMBRANE-PROTEINS IN POLARIZED KIDNEY-CELLS

Segregation of lysosomal membrane proteins into the endosomal system o ccurs via clathrin coated vesicles, either from the trans-Golgi networ k or the cell surface. in both cases, cytosolic signals present in the se proteins interact with clathrin adaptor proteins. In polarized kidn ey MDCK cells, transport of lysosomal membrane proteins via the plasma membrane occurs in a polarized fashion through the basolateral domain . Here, we discuss recent developments on lysosomal membrane protein t rafficking, with a particular focus on the transport of these proteins in polarized MDCK cells.