EFFECT OF VITAMIN-C ON PROSTATILENE MUTAG ENICITY IN MICE

Frequencies of sperm head anomalies (SHA) and chromosome aberrations ( CA) in bone marrow cells were studied after injection of drugs, prosta tilene and vitamin C into the male mice Mus musculus. It was found tha t prostatilene (5, 10 and 50 mkg) increased the frequency of both SHA and CA. Vitamin C (14 and 140 mkg) induced no CA but increased SHA fre quency at the dose of 140 mkg. The joint action of the drugs led to de crease in SHA frequency for all dose combinations. Antimutagenic actio n of vitamin C in the CA test was recorded for only 14 mkg dose.