MOUSE MINISATELLITE MUTATIONS INDUCED BY IONIZING-RADIATION

Male (101/HY x C3H/SnY) F1-hybrid mice were given an acute exposure to 0,5 or 1 Gy gamma-irradiation using Co-60, and DNA fingerprints were produced from parents and progeny using probes 33.6 and 33.15. The fre quency of mutations in the offspring of irradiated males was 1.72 time s higher than in offspring of nonirradiated males. Possible implicatio ns of the DNA fingerprint technique in monitoring of mutations in huma n populations are discussed.