NIOSOMAL PLUMBAGIN WITH REDUCED TOXICITY AND IMPROVED ANTICANCER ACTIVITY IN BALB C MICE/

Plumbagin niosomes were prepared using a lipid layer hydration method, and drug entrapment was measured. The acute toxicity studies were con ducted following treatment with free and niosomal plumbagin. The antit umour activity of niosomal plumbagin in a solid tumour (sarcoma-180) a nd Ehrlich ascites model was evaluated. Niosome-encapsulated plumbagin was less toxic than free drug. The antitumour activity of the drug wa s also better after encapsulation. The better anticancer activity can be justified with the help of LD50 survival studies and study of tumou r volume doubling time.