DISPOSITION AND DISTRIBUTION OF THE CYTIDINE CYANOBORANE ADDUCT, [2-C-14]-2'-DEOXYCYTIDINE-3N-CYANOBORANE, IN CF1 MICE

2'-Deoxycytidine-3N-cyanoborane (dC-BH2CN) had been found to possess c ytotoxic, hypolipidaemic, and anti-inflammatory activity; its disposit ion in mice was investigated in this report. The half-life of dC-BH2CN was found to be 0.3 hours and 2'-deoxycytidine was identified as one metabolite. A second elimination rate-limited metabolite was also form ed, but was not identified. dC-BH2CN was taken up in vitro in human BG -9 fibroblasts, rat red blood cells, and murine Tmolt3 cells, and in v ivo in Ehrlich ascites carcinoma cells. In the Ehrlich ascites tumour, concentrations of dC-BH2CN were 4- to 8-fold higher than liver and pl asma from 2 to 24 hours after administration.