Bs. Burnham et al., DISPOSITION AND DISTRIBUTION OF THE CYTIDINE CYANOBORANE ADDUCT, [2-C-14]-2'-DEOXYCYTIDINE-3N-CYANOBORANE, IN CF1 MICE, Drug investigation, 6(2), 1993, pp. 75-82
2'-Deoxycytidine-3N-cyanoborane (dC-BH2CN) had been found to possess c
ytotoxic, hypolipidaemic, and anti-inflammatory activity; its disposit
ion in mice was investigated in this report. The half-life of dC-BH2CN
was found to be 0.3 hours and 2'-deoxycytidine was identified as one
metabolite. A second elimination rate-limited metabolite was also form
ed, but was not identified. dC-BH2CN was taken up in vitro in human BG
-9 fibroblasts, rat red blood cells, and murine Tmolt3 cells, and in v
ivo in Ehrlich ascites carcinoma cells. In the Ehrlich ascites tumour,
concentrations of dC-BH2CN were 4- to 8-fold higher than liver and pl
asma from 2 to 24 hours after administration.