Mt. Makler et al., PARASITE LACTATE-DEHYDROGENASE AS AN ASSAY FOR PLASMODIUM-FALCIPARUM DRUG-SENSITIVITY, The American journal of tropical medicine and hygiene, 48(6), 1993, pp. 739-741
Citations number
7
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
This report compares the use of the lactate dehydrogenase (pLDH) assay
with 3H-hypoxanthine incorporation and Giemsa microscopy for the eval
uation of anti-malaria drug inhibition of the growth of P. falciparum
in vitro. The inhibition profiles and IC50 determinations of the pLDH
assay were directly comparable to those determined by the radioactive
uptake and microscopic methods. Furthermore, the pLDH culture sensitiv
ity assay is reproducible, easily interpreted, rapid and inexpensive t
o perform, suggesting field applicability.