Tv. Kot et al., PREVENTING ACUTE GOUT WHEN STARTING ALLOPURINOL THERAPY - COLCHICINE OR NSAIDS, Medical journal of Australia, 159(3), 1993, pp. 182-184
Acute gout is a well known complication of the commencement of allopur
inol therapy. Prophylaxis is needed for some months, even after serum
urate levels have returned to normal. Colchicine is usually preferable
to NSAIDs for this purpose, being cheaper, and better tolerated, espe
cially in patients with peptic ulcer, gastrointestinal bleeding or dys
pepsia or who are taking anticoagulants.