RECOMBINANT IMMUNOTOXINS - NEW THERAPEUTIC AGENTS FOR CANCER-TREATMENT

Authors
PASTAN IH
Citation
Ih. Pastan, RECOMBINANT IMMUNOTOXINS - NEW THERAPEUTIC AGENTS FOR CANCER-TREATMENT, Cancer detection and prevention, 17(2), 1993, pp. 289-293
Citations number
NO
Categorie Soggetti
Oncology
Journal title
Cancer detection and prevention → ACNP
ISSN journal
0361090X
Volume
17
Issue
2
Year of publication
1993
Pages
289 - 293
Database
ISI
SICI code
0361-090X(1993)17:2<289:RI-NTA>2.0.ZU;2-0
Abstract
We have developed new agents for the treatment of cancer by geneticall y modifying Pseudomonas exotoxin. We have deleted the cell-binding reg ion of Pseudomonas exotoxin and replaced it with various growth factor s or the combining regions of antibodies in a single chain form. These new recombinant molecules are called recombinant toxins. Several diff erent types of recombinant toxins have been produced. B3(Fv)-PE38KDEL is a recombinant toxin that kills many different adenocarcinomas and e pidermoid carcinomas. The molecule is now undergoing preclinical devel opment.