ANALYSIS OF THE 5-HT(1C) RECEPTOR AND THE SEROTONIN UPTAKE SITE IN FAWN-HOODED RAT-BRAIN

Both the 5-HT1C receptor and the 5-HT uptake binding sites were measur ed in Fawn-Hooded, Sprague-Dawley and Wistar rats. Five brain regions were examined: frontal cortex, hippocampus, striatum, hypothalamus, an d brainstem. We found significant differences in the B(max) and K(d) v alues in various brain regions comparing Fawn-Hooded rats, with Spragu e-Dawley and Wistar animals. The regional differences in receptor numb er and affinity in both the 5-HT1C receptor and the 5-HT uptake site i n the Fawn-Hooded strain, relative to Wistar and Sprague-Dawley animal s, provide support for the use of the Fawn-Hooded rat in serotonin dys function studies.