METABOTROPIC GLUTAMATE RECEPTORS CONTRIBUTE TO THE INDUCTION OF LONG-TERM DEPRESSION IN THE CA1 REGION OF THE HIPPOCAMPUS

Authors
BASHIR ZI JANE DE SUNTER DC WATKINS JC COLLINGRIDGE GL
Citation
Zi. Bashir et al., METABOTROPIC GLUTAMATE RECEPTORS CONTRIBUTE TO THE INDUCTION OF LONG-TERM DEPRESSION IN THE CA1 REGION OF THE HIPPOCAMPUS, European journal of pharmacology, 239(1-3), 1993, pp. 265-266
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
239
Issue
1-3
Year of publication
1993
Pages
265 - 266
Database
ISI
SICI code
0014-2999(1993)239:1-3<265:MGRCTT>2.0.ZU;2-S
Abstract
Long-term depression of synaptic transmission was induced following th e prior induction of long-term potentiation in the CA1 region of rat h ippocampal slices. We show that the induction of this form of synaptic depression can be prevented by (+)-alpha-methyl-4-carboxyphenylglycin e, a selective antagonist of metabotropic glutamate receptors.