5-HT1A, 5-HT1D, 5-HT2 binding sites and affinity and 5-HT uptake sites
were simultaneously determined in frontal cortex samples from 23 cont
rol subjects, aged 16-75 years. A significant reduction in the number
of 5-HT1D and 5-HT2 binding sites was found with regard to age, togeth
er with a significant decrease in the 5-HT2 binding affinity. It is su
ggested that the total 5-HT, age-related loss described in previous st
udies could be ascribed to the 5-HT1D subtype. Furthermore, aging does
not seem to be associated with a reduced cortical serotonergic innerv
ation, as indicated by the stability of the [H-3]paroxetine-labeled 5-
HT uptake sites.