DIHYDROFOLATE-REDUCTASE AND THYMIDYLATE SYNTHASE IN PLANTS - AN OPEN PROBLEM

Authors
CELLA R PARISI B
Citation
R. Cella et B. Parisi, DIHYDROFOLATE-REDUCTASE AND THYMIDYLATE SYNTHASE IN PLANTS - AN OPEN PROBLEM, Physiologia Plantarum, 88(3), 1993, pp. 509-521
Citations number
80
Categorie Soggetti
Plant Sciences
Journal title
Physiologia Plantarum → ACNP
ISSN journal
00319317
Volume
88
Issue
3
Year of publication
1993
Pages
509 - 521
Database
ISI
SICI code
0031-9317(1993)88:3<509:DATSIP>2.0.ZU;2-8
Abstract
This review deals with recent findings in the purification and charact erization of dihydrofolate reductase (DHFR) and thymidylate synthase ( TS) in plants. The few enzymes purified, which differ remarkably in re gard to their structure, kinetic and molecular properties and subcellu lar location are described. The response of DHFRs to antifolic agents and the analysis of resistance mechanisms in isolated cell lines is al so reported. Problems opened by recent studies of the enzymes isolated from plants are outlined.