CISPLATIN-RESISTANT METASTATIC HEPATOBLASTOMA - COMPLETE RESPONSE TO CARBOPLATIN, ETOPOSIDE, AND LIVER-TRANSPLANTATION

A child with stage 4 hepatoblastoma failed to respond to treatment wit h cisplatin and adriamycin. She then showed a response to carboplatin with complete clearing of pulmonary metastases. Bilobar liver disease persisted, although significantly reduced in size. A liver transplant was subsequently performed and she remains in complete remission 36 mo nths later. After the first course of carboplatin, there was a dramati c rise in alpha-feto protein which then fell exponentially. Carboplati n warrants further study in hepatoblastoma. (C) 1993 Wiley-Liss, Inc.