POSSIBILITY OF TARGETING TREATMENT FOR ISCHEMIC-HEART-DISEASE WITH LIPOSOME .2.

Studies on the isolated rat heart perfusion model have proved that per fusion with high Ca2+ (4.5 mmol/L), high K+ (8.7 mmol/L) or free radic al generating system (FRGS) significantly increases myocardial uptake of liposomes. Intravenous injection of liposomes covalently combined w ith antibody of rat myocardial cells obviously elevates the target act ion of liposomes to myocardium. Liposome-carried SOD for treatment of rat myocardial ischemia-reperfusion injury is much more effective than simple SOD. The results evidence that the liposome as drug carrier fo r treatment of ischemic heart diseases shows a broad prospect for its clinical use.