S. Kahraman et al., EFFECT OF PREOPERATIVE I M ADMINISTRATION OF DICLOFENAC ON SUXAMETHONIUM-INDUCED MYALGIA, British Journal of Anaesthesia, 71(2), 1993, pp. 238-241
We have studied the effects of preoperative administration of diclofen
ac on suxamethonium-induced myalgia, plasma met-enkephalin-like activi
ty (E-LA), prostaglandin E2-like activity (PGE2-LA), leukotriene C4-li
ke activity (LTC4-LA) and histamine-like activity (H-LA). Thirty-four
ASA I patients undergoing elective ophthalmic surgery were allocated r
andomly to two groups to receive either saline placebo or diclofenac 7
5 mg i.m. 20 min before operation, in a double-blind design. Anaesthes
ia was induced with thiopentone 5-7 mg kg-1 followed by suxamethonium
1. 5 mg kg-1 and maintained with 67% nitrous oxide and halothane in ox
ygen. Plasma PGE2-LA, LTC4-LA, H-LA and E-LA were measured before prem
edication, 1 min after the administration of suxamethonium and 24 h af
ter operation. Muscle fasciculations, intubation conditions and postop
erative myalgia were graded numerically. Postoperative myalgia in the
diclofenac group was significantly (P < 0.05) less (47.1%) than in the
control gro up (76.5%). Post-suxamethonium and 24-h concentrations of
plasma PGE2-LA and LTC4-LA were also significantly (P < 0.05) greater
than baseline in the control group. Plasma H-LA was increased in both
groups after suxamethonium and this increase was significant (P < 0.0
5) in the control group. We conclude that diclofenac reduces significa
ntly the incidence and intensity of suxamethonium-induced myalgia.