DOBUTAMINE STRESS ECHOCARDIOGRAPHY IDENTIFIES HIBERNATING MYOCARDIUM AND PREDICTS RECOVERY OF LEFT-VENTRICULAR FUNCTION AFTER CORONARY REVASCULARIZATION
Cg. Cigarroa et al., DOBUTAMINE STRESS ECHOCARDIOGRAPHY IDENTIFIES HIBERNATING MYOCARDIUM AND PREDICTS RECOVERY OF LEFT-VENTRICULAR FUNCTION AFTER CORONARY REVASCULARIZATION, Circulation, 88(2), 1993, pp. 430-436
Background. The identification of hibernating myocardium is important
in selecting patients who will benefit from coronary revascularization
. This study was performed to determine whether dobutamine stress echo
cardiography (DSE) could identify hibernating myocardium and predict i
mprovement in regional systolic wall thickening after revascularizatio
n. Methods and Results. DSE was performed in 49 consecutive patients w
ith multivessel coronary disease and depressed left ventricular functi
on. Contractile reserve during DSE was defined by the presence of two
criteria: (1) improved systolic wall thickening in at least two adjace
nt abnormal segments and (2) greater-than-or-equal-to 20% improvement
in regional wall thickening score. Postoperative echocardiograms were
evaluated for improved regional wall thickening in 25 patients at leas
t 4 weeks after successful coronary revascularization. All studies wer
e read in blinded fashion. Contractile reserve during DSE was present
in 24 (49%) of 49 patients. The presence or absence of contractile res
erve on preoperative DSE predicted recovery of ventricular function in
the 25 patients who underwent successful revascularization. Thus, 9 o
f 11 patients with contractile reserve had improved systolic wall thic
kening after revascularization (hibernating myocardium), whereas 12 of
14 patients without contractile reserve did not improve (P=.003). Con
clusions. Dobutamine stress echocardiography provides a simple, cost-e
ffective, and widely available method of identifying hibernating myoca
rdium and predicting improvement in regional left ventricular wall thi
ckening after coronary revascularization. This technique may be clinic
ally valuable in the selection of patients for coronary revascularizat
ion.