We studied 6 patients with myoclonus elicited by flash stimulation (1
- 15 Hz). Multichannel electromyographic recording showed a rostrocaud
al recruitment order for the generalized myoclonic jerk. In all patien
ts, each flash induced a large (36.9 +/- 5.7 muV) frontal biphasic wav
e with an onset latency of 42 msec that preceded the earliest muscle r
esponse in the face by at least 4 msec (range, 4-7 msec), the activity
in the biceps by 11 to 14 msec, and the activity in tibialis anterior
by 26 to 34 msec. Occipital potentials evoked by the same flash stimu
lation had a latency of 33.7 msec and were of normal amplitude (2.1 +/
- 1.2 muV). Brain-mapping analysis indicated that the frontal activity
correlated with the myoclonus originated in the premotor and motor co
rtices. These findings provide evidence for a cortical origin of this
form of stimulus-sensitive myoclonus in humans. Administration of apom
orphine and lisuride (intravenously) and levodopa-carbidopa (orally) a
bolished the photic myoclonus. Intravenous 5-hydroxytryptophan plus ca
rbidopa (orally) and piracetam (orally) were also effective against ph
otic myoclonus. The wide range of drugs active against photic cortical
myoclonus suggests the participation of several biochemical mechanism
s in its origin.