Omeprazole is a proton pump inhibitor widely used for the treatment of
peptic ulcer disease. We report a patient presenting nonoliguric acut
e renal failure following omeprazole treatment. Both eosinophilia and
eosinophiluria were observed, and the patient was diagnosed as having
drug-induced acute interstitial nephritis. Renal failure spontaneously
resolved when omeprazole was discontinued.