GENERALIZED ERUPTIVE KERATOACANTHOMA OF GRZYBOWSKI

A patient with generalized eruptive keratoacanthoma of Grzybowski is d escribed. Our findings, along with those of the 21 reported cases from the world literature, are summarized. This rare variant of keratoacan thoma most commonly affects patients in the fifth to seventh decades o f life and appears as a generalized eruption of hundreds to thousands of follicular papules. These small papules often have a keratotic cent er and demonstrate the microscopic features of keratoacanthoma. Marked facial involvement is characteristic and can lead to masked facies wi th ectropion. Severe pruritus, mucosal lesions, and koebnerization are features of the disease. The course is chronic and the response to th erapy is poor, although a few patients have improved with the use of s ystemic retinoids.