The poor results of the National Breast Screening Study of Canada rega
rding the screening of women aged 40-49 have been interpreted to sugge
st that mammography might be detrimental. Our comparison of women who
had mammography and had their cancers detected by mammography with wom
en who did not have mammography and had palpable cancers suggest that
this is not the case. There is no detrimental effect; rather, the use
of mammography results in an improvement in survival. The poor results
of the National Breast Screening Study likely are due to the unbalanc
ed allocation of women with advanced cancers to the screened group, th
e poor quality of the mammography in the trial, and an insufficient sa
mple size.