PURITY EVALUATION OF 6-ALPHA-METHYLPREDNISOLONE ACETATE BY HPLC

Authors
SIGNORETTI EC VALVO L SAVELLA AL CAVINA G
Citation
Ec. Signoretti et al., PURITY EVALUATION OF 6-ALPHA-METHYLPREDNISOLONE ACETATE BY HPLC, Journal of pharmaceutical and biomedical analysis, 11(7), 1993, pp. 587-593
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
11
Issue
7
Year of publication
1993
Pages
587 - 593
Database
ISI
SICI code
0731-7085(1993)11:7<587:PEO6AB>2.0.ZU;2-2
Abstract
A high-performance liquid chromatographic method is described for the analysis and identification of related impurities in pharmaceutical-gr ade 6alpha-methylprednisolone acetate (MPA). Eight MPA impurities deri ved from synthesis and/or degradation processes were identified. The m ethod is compared to other analytical procedures recently proposed for the European Pharmacopoeia.