SEIZURE RESULTING FROM A VENLAFAXINE OVERDOSE

OBJECTIVE: TO report a case of venlafaxine overdose. CASE SUMMARY: A 4 0-year-old white woman with major depression took an overdose of venla faxine in an apparent suicide attempt. After the ingestion of 26 venla faxine 50-mg tablets, the patient experienced a witnessed generalized seizure. She was admitted to the medical intensive care unit, venlafax ine was discontinued, and no further sequelae were seen. DISCUSSION: T o our knowledge, this is the first reported case of venlafaxine overdo se that resulted in a generalized seizure. Based on nonoverdose pharma cokinetics and pharmacodynamics of venlafaxine and the potential risks of available interventions, no emergent therapy was instituted. CONCL USIONS: The venlafaxine overdose in our patient resulted in a single e pisode of generalized seizure but elicited no further sequelae.