SITE-SPECIFIC PHOTO-CROSS-LINKING OF SINGLE-STRANDED OLIGONUCLEOTIDESBY A COMPLEMENTARY SEQUENCE EQUIPPED WITH AN INTERNAL PHOTOACTIVE PROBE

Authors
SAINTOME C CLIVIO P FAVRE A FOURREY JL LAUGAA P
Citation
C. Saintome et al., SITE-SPECIFIC PHOTO-CROSS-LINKING OF SINGLE-STRANDED OLIGONUCLEOTIDESBY A COMPLEMENTARY SEQUENCE EQUIPPED WITH AN INTERNAL PHOTOACTIVE PROBE, Chemical communications, (2), 1997, pp. 167-168
Citations number
28
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
2
Year of publication
1997
Pages
167 - 168
Database
ISI
SICI code
1359-7345(1997):2<167:SPOSO>2.0.ZU;2-3
Abstract
The photo-crosslinking behaviour of oligonucleotide constructs, incorp orating photoactive residues 1-5 at a defined position, has been exami ned in the presence of their DNA (14-mer) and RNA (15-mer) complementa ry targets using a two-fold excess; it revealed a moderate but promisi ng irreversible binding efficiency, the results of which could be anti cipated by molecular mechanics in the case of 4.