NEUROCHEMICAL STUDIES IN SCHIZOPHRENIA

This paper describes the development of one approach to neurochemical research into schizophrenia, from a search for abnormal concentrations of a psychoactive compound to the finding of abnormalities of markers for GABA and glutamate neurotransmitter systems in brain tissue from schizophrenic patients. The dopamine hypothesis of schizophrenia has p layed a central role in the formulation of the research strategies use d in this work.