THE ISOLATION OF CARNOSIC ACID 12-METHYL ETHER FROM SALVIA-OFFICINALIS L AND NMR-STUDY OF ITS METHYL-ESTER

In continuation of our studies on the chemical compositions of the aer ial parts of cultivated Salvia officinalis L., we have isolated the ti tle substance for the first time in this type of Sage. The structure o f the isolated compound was established by spectroscopic data and some chemical reactions. Investigation of H-1 and C-13 NMR, homonuclear (C OSY) (H-1-H-1), heteronuclear (HETCOR) (H-1-C-13), and selective INEPT spectra, permitted the unambiguous assignment of the H-1 and C-13 NMR spectra, what gave the possibility to resolve the signals of similar natural products.