EFFICIENT UTILIZATION OF [C-14] CARBON-DIOXIDE AS A PHOSGENE EQUIVALENT FOR LABELED SYNTHESIS

Authors
DEAN DC WALLACE MA MARKS TM MELILLO DG
Citation
Dc. Dean et al., EFFICIENT UTILIZATION OF [C-14] CARBON-DIOXIDE AS A PHOSGENE EQUIVALENT FOR LABELED SYNTHESIS, Tetrahedron letters, 38(6), 1997, pp. 919-922
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
6
Year of publication
1997
Pages
919 - 922
Database
ISI
SICI code
0040-4039(1997)38:6<919:EUO[CA>2.0.ZU;2-I
Abstract
Addition of one equivalent [C-14]carbon dioxide to primary or secondar y amines in the presence of ternary base, followed by reaction of the resulting [C-14]carbamate salt with phosphorus oxychloride or thionyl chloride, represents a cost effective alternative to labeled phosgene. (C) 1997, Elsevier Science Ltd.