CHEMICAL MODIFICATIONS OF THE PROPYLBENZILYLCHOLINE MUSTARD COVALENTLY ATTACHED TO THE MUSCARINIC CHOLINERGIC RECEPTOR

Authors
ALPERIN DM BOUZAT CB
Citation
Dm. Alperin et Cb. Bouzat, CHEMICAL MODIFICATIONS OF THE PROPYLBENZILYLCHOLINE MUSTARD COVALENTLY ATTACHED TO THE MUSCARINIC CHOLINERGIC RECEPTOR, Anales de la Asociacion Quimica Argentina, 81(2-3), 1993, pp. 205-212
Citations number
10
Categorie Soggetti
Chemistry
Journal title
Anales de la Asociacion Quimica Argentina → ACNP
ISSN journal
03650375
Volume
81
Issue
2-3
Year of publication
1993
Pages
205 - 212
Database
ISI
SICI code
0365-0375(1993)81:2-3<205:CMOTPM>2.0.ZU;2-G
Abstract
Propylbenzilylcholine mustard covalently labels the muscarinic choline rgic receptor through a pronase-susceptible linkage. Chemical characte rization of the tritiated compound released by pronase from the solubi lized receptor suggest that it corresponds to the ligand lacking its ( 2,2-(diphenyl), 2-hydroxy)-acetate moiety due to a spontaneous intramo lecular hydrolysis. The labelled compound is released only from the un folded receptor and by esterolytic agents.