SOLID-PHASE SYNTHESIS OF HETEROCYCLIC-COMPOUNDS FROM LINEAR PEPTIDES - CYCLIC UREAS AND THIOUREAS

Authors
NEFZI A OSTRESH JM MEYER JP HOUGHTEN RA
Citation
A. Nefzi et al., SOLID-PHASE SYNTHESIS OF HETEROCYCLIC-COMPOUNDS FROM LINEAR PEPTIDES - CYCLIC UREAS AND THIOUREAS, Tetrahedron letters, 38(6), 1997, pp. 931-934
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
6
Year of publication
1997
Pages
931 - 934
Database
ISI
SICI code
0040-4039(1997)38:6<931:SSOHFL>2.0.ZU;2-#
Abstract
The solid phase synthesis of cyclic ureas and thioureas is described. The reduction of acylated dipeptides followed by treatment with carbon yldiimidazole or thiocarbonyldiimidazole affords the corresponding cyc lic urea or thiourea in good yield and high purity. This is an example of a broader approach to the solid phase synthesis of individual hete rocyclic compounds and combinatorial libraries using peptides as start ing materials. (C) 1997, Elsevier Science Ltd.