IMPORTANCE OF INTERLEUKIN-3 ON HISTAMINE-RELEASE FROM HUMAN BASOPHILS

Authors
SUGIYAMA H EDA R HOPP RJ BEWTRA AK TOWNLEY RG
Citation
H. Sugiyama et al., IMPORTANCE OF INTERLEUKIN-3 ON HISTAMINE-RELEASE FROM HUMAN BASOPHILS, Annals of allergy, 71(4), 1993, pp. 391-395
Citations number
19
Categorie Soggetti
Allergy
Journal title
Annals of allergy → ACNP
ISSN journal
00034738
Volume
71
Issue
4
Year of publication
1993
Pages
391 - 395
Database
ISI
SICI code
0003-4738(1993)71:4<391:IOIOHF>2.0.ZU;2-8
Abstract
We investigated the effects of interleukin-3 (IL-3) on histamine relea se (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine re lease (HR) in selected donors (IL-3 responders) and enhanced anti-IgE- induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced H R and spontaneous histamine release (r = .8532, P < .0001).