The utility of randomised, double-blind, controlled, comparative local
anaesthetic blocks for the diagnosis of cervical, zygapophysial joint
pain was studied in 47 patients with chronic neck pain following whip
lash injury. Each patient was investigated with radiologically control
led blocks of the medial branches of the cervical, dorsal rami to anae
sthetise the target cervical, zygapophysial joint. The blocks were per
formed using either lignocaine or bupivacaine, randomly allocated, and
the patients' responses were assessed in a double-blind fashion. Any
positive response was subsequently assessed by repeating the block wit
h the complementary anaesthetic. Only those patients experiencing a lo
nger period of pain relief from the bupivacaine were considered to hav
e true-positive responses. Forty-four patients had pain relief from tw
o blocks at a single level, of whom 34 had longer pain relief from bup
ivacaine. This result is unlikely to have occurred by chance (P = 0.00
02). The durations of pain relief obtained from the anaesthetics were
consistent with the known characteristics of these drugs with bupivaca
ine lasting significantly longer than lignocaine (P = 0.0003). A subgr
oup of 13 patients were identified with unexpected, prolonged response
s to one or both of the anaesthetics. Comparative, diagnostic blocks a
re a valid technique in the identification of painful zygapophysial jo
ints, and constitute an implementable alternative to normal saline con
trols.